Does Retin-A/Tretinoin cream or lotion really work for getting rid of lines, wrinkles and sun-damage? The answer is a resounding "YES!"
A study published in the Journal of the American Medical Association showed that topical tretinoin/Retin-A, a vitamin-A derivative used for the treatment of common acne, can make a significant improvement in aging skin.
**Interestingly the singer/actress Cher credits the daily application of Retin-A cream for her lack of crows feet around the eyes, as well as extremely youthful-looking skin.
The 16-week study conducted by John J. Voorhees, M.D. of the University of Michigan Medical Center and his colleagues, was a randomized, double-blind study of topical tretinoin in the treatment of photo-aging. This means that that neither patients or the dermatologists knew which cream contained Retin-A and which was plain, until the Retin-A began to work.
The 30 patients tested had skin samples taken and analyzed. The before and after pictures showed a dramatic change over time. Fourteen of the 15 patients who received tretinoin to the face had improvement in photoaging, whereas none of the plain cream treated patient's faces improved.
Controlled clinical studies have proven that photo-damaged (sun-damaged) skin responds favorably to Retin-A. Retin-A stimulates the skin to step up cell production and promotes the development of the underlying layers of the skin.
With tretinoin, new skin cells push toward the surface and this clears the skin of dead cells and other debris. There's a fading of age spots, and a stimulation of collagen production. At the same time there's an increase in the amount of blood circulating to the skin, and the skin has a healthier appearance. Cell growth becomes more even.
Physicians always have closely observed the effects of tretinoin on the skin. The drug (available by prescription only) begins to work almost immediately following application. Within a week changes begin to occur. The activity goes on for some weeks before patients can actually see the changes. There's also cheaper generic brands of Retin-A which work just as well.
preventive measure to retard and decelerate photo-aging; thus, tretinoin is ideal as a part of a woman's daily skin care regime (it is a part of mine!)